Scotland flanker Andrew Mower is out of the World Cup after sustaining a serious knee injury during a training session on Wednesday.
The 28-year-old, who won his 13th cap in the recent warm-up Test against Wales, pulled up during training and was taken to hospital in Brisbane.
A scan showed that he had damaged the medial meniscus and that he would also require anterior cruciate ligament reconstruction.
Mower had missed the opening victory over Japan with a knee problem caused by another training ground incident but was expected to be fit to face the USA on 20 October.
Scotland manager Dougie Morgan said: "We're all saddened that Andrew's World Cup has ended in this manner.
"The injury is unrelated to the knee knock which prevented him from being involved in the match against Japan last weekend.
"We are considering overnight who we will call for as a replacement from home and an announcement will be made tomorrow from our training camp on the Sunshine Coast."