Big-serving seventh seed Jo-Wilfried Tsonga takes on American wildcard Chase Buchanan, the US national junior champion, in his first-round match
Buchanan, at 18 the youngest man in this year's tournament, cannot live with the powerful Frenchman and bows out after winning only three games in a one-sided match
But home fans do get to cheer an upset when qualifier Jesse Witten shocks 29th seed Igor Andreev of Russia with a thumping 6-4 6-0 6-2 victory - his first win at ATP Tour level
Women's sixth seed Svetlana Kuznetsova makes a slow start against Germany's Julia Goerges and is broken twice early in the opening set
But Kuznetsova, the 2004 US Open champion, recovers well and wins 10 of the next 12 games to complete what turns out to be a comfortable victory
Another women's seed to make comfortable progress is Denmark's Caroline Wozniacki, seeded ninth, who beats Galina Voskoboeva of Kazakhstan 6-4, 6-0
But it is far from plain sailing for world number one Dinara Safina, who finds herself in deep trouble when she loses the first set against 18-year-old wildcard Olivia Rogowska
Australian Rogowska, making her US Open debut in the Arthur Ashe Stadium, has a point for a 4-0 lead in the deciding set, but Safina comes up with a winner
And in a dramatic match littered with errors, teenager Rogowska is broken at 4-4 and Safina comes through after two and a half hours
Fourth seed and 2007 finalist Novak Djokovic opens his campaign against former world number three Ivan Ljubicic
There is room for a few more on the Grandstand court where American Ryan Sweeting loses in straight sets to Marin Cilic
Cilic, the 16th seed, remains on course for a fourth-round meeting with world number two Andy Murray after a 7-6 6-4 7-6 win
Jelena Jankovic dazzles in a red dress on Louis Armstrong Stadium, and she easily beats Roberta Vinci in her opening match
Ana Ivanovic, seeded 11th, has a tough time on Louis Armstrong Stadium as she loses to Ketryna Bondarenko of Ukraine in a final set tie-break
Maria Sharapova, the 2006 champion, makes a solid start against Bulgaria's Tsvetana Pironkova on her return to Flushing Meadows after missing last year with a shoulder injury
Andy Murray has the honour of playing in the night session match and he takes on Ernests Gulbis on the Arthur Ashe Stadium
Murray is in control for the most part, although there are a few worrying moments when he takes a heavy fall while chasing down a shot
Murray eventually comes through 7-5 6-3 7-5 for his fourth career win over Gulbis, and he will play Paul Capdeville of Chile in round two
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