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The Today programme is live from the site of the 2012 Games which, after seven years of planning, are opened tonight when the Olympic flame is lit, and the world's greatest sporting festival begins. The United Nations has been trying to reach a deal to regulate the global arms trade which is worth £50bn every year. And also on today's programme, a reason to frown or smile? It's ten years since botox was first used for wrinkles.

We are no longer providing clips of every part of the programme but you will be able to listen via the BBC iPlayer .

Due to rights restrictions, internet streaming is unavailable outside the UK for anything broadcast from the Olympic park, click here for more information

0615
Business news with Lesley Curwen: Shares in the US social network site Facebook have sunk to a new low.

0709

A group of doctors and nurses are calling for all hospitals in the NHS to use the same type of chart at a patient's bedside to monitor their vital signs. Professor Bryan Williams, chair of the working party that came up with the proposal to standardise charts, explains why he believes standardisation is needed.

0713
Ric Birch, who directed the opening ceremony for the Sydney Games in 2000, and has been involved in six Olympic openings explains what you have to do to plan a successful one.

0719
Business news with Lesley Curwen.

0722
Chinese state media has been reporting that the wife of the politician Bo Xilai has been charged with the murder of the British businessman Neil Heywood. John Sudworth reports.

0724
At 0812 bells all across the UK will be rung for three minutes as part of the Cultural Olympiad to mark the opening of the Olympic and Paralympic Games. Mike McCann, the Palace Keeper of the Clock, explains the historical significance for Big Ben.

0727
Sport news with Rob Bonnet, live from the Olympic Park.

0735
Andy Hunt, chef de mission of Team GB, gives his forecast on what lies ahead for the British team in terms of medals over the next two weeks.

0740
The paper review.

0743
Dame Mary Peters, who was pentathlon winner in 1972 at the Munich Games, recalls participating in an event which encompassed one of the darkest episodes in Olympic history, the attack on Israeli athletes in the village in which 11 people were murdered.

0747
Thought for the day with Canon Duncan Green, head of Multi-Faith Chaplaincy Services for the 2012 Games.

0750

Andy Hosken speaks to Timothy Ray Brown, the first person in the world known to have recovered from HIV, and Dr Ravindra Gupta, a research fellow at UCL, gives his thoughts on the chances of finding a treatment for the millions of people currently living with HIV.

0810
Mayor of London Boris Johnson speaks to Jim Naughtie from the Olympic Park as bells from across the country are rung to to mark the opening of the Games.

0820

In Archive on 4 on Saturday, the New York Times columnist Maureen Dowd questions whether Marilyn Monroe really was as dumb as was made out, or whether she was just the victim of a society that cannot accept that a beautiful woman can be bright too. Author Lois Banner and columnist Dame Ann Leslie, who has interviewed Marilyn's psychiatrist, debate.

0826
Sport news with Rob Bonnet, live from the Olympic Park.

0833

The United Nations has been trying to reach a deal to regulate the global arms trade which is worth £50bn every year. Anna MacDonald, head of arms control at Oxfam, and Col Bob Stewart, debate how this can be achieved.

0839
Business news with Lesley Curwen.

0842
Sir John Major, former prime minister and a keen sport enthusiast, speaks to Jim Naughtie ahead of the Olympic opening ceremony.

0849

It is ten years since Botox was approved for cosmetic use in the United States. Author Natasha Walter, and consultant cosmetic surgeon Adrian Richards, debate the controversial treatment.

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