The Southmead site will be redeveloped
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Plans to shake-up healthcare provision in Bristol were approved on Monday.
Southmead Hospital is to host Bristol's new 'super-hospital' in the �500m revamp as it offers more space and more options for expansion than Frenchay.
Experts decided Frenchay would cost too much to develop and it will become a community hospital.
Plans to close Cossham Hospital in Kingswood were recently withdrawn after protests from residents.
The proposals were approved by a committee made up of NHS and Primary Care Trusts affected by the plans.
'No losers'
The new hospital on the Southmead site will cost around �280m and will not open before 2012.
Dr Martin Morse, medical director for the North Bristol NHS Trust, said: "There are no winners and losers; this is beneficial to healthcare."
But some residents had protested against the downgrading of Frenchay.
Steve Webb, Lib Dem MP for Northavon, said: "We're not going to give up. We're not going to take this lying down."
The decision is due before the Strategic Health Authority in the coming weeks.
Other proposals accepted include:
Consolidating children's services at the Children's HospitalA new community hospital in south Bristol and in YateA new community healthcare centre in central and east BristolThe closure of Bristol General HospitalRevamping the BRIMoving A&E to Frenchay from Southmead as an interim measure