Veteran French star Amelie Mauresmo - a two-time semi-finalist at Flushing Meadows - gets off to a solid start in her second-round match with Canada's Aleksandra Wozniak
Mauresmo leads 2-0 in the first set but then collapses spectacularly, losing 12 of the next 14 games against the world number 39, who wins 6-4 6-0 to reach round three for the first time
But the heaviest defeat of the day in New York is suffered by India's Sania Mirza, who is thumped 6-0 6-0 by 10th seed Flavia Pennetta
Mirza makes 28 unforced errors but afterwards pays tribute to in-form Italian Pennetta, who produces a powerful display of attacking tennis
Flamboyant French star Gael Monfils begins his US Open campaign with an impressive display against compatriot Jeremy Chardy
Monfils, the 13th seed, completes a straightforward 6-1 6-4 6-3 victory and has more problems getting past a pack of autograph hunters afterwards
Former world number one Marat Safin, in his final Grand Slam before he retires at the end of the year, still has time to test out the umpire as he takes on Jurgen Melzer
Safin, the US Open champion in 2000, makes a storming start and takes the opening set before Austrian Melzer begins to fight back
Safin sees the second and third sets slide away and Melzer completes his victory when the 29-year-old Russian punches a backhand into the net
Safin, who also won the 2005 Australian Open, smiles as he milks the applause of the crowd at the Louis Armstrong Stadium before making his final exit at Flushing Meadows
Bethanie Mattek-Sands hopes to make the most of any lack of mobility caused by Venus Williams' knee injury when she takes on the third seed
But Venus, who came within three points of defeat in round one, never looks like being upset by the world number 124 and completes a comfortable 6-4 6-2 victory
Kim Clijsters, the 2005 US Open champion, looks to extend her impressive run since returning to tennis after a two-year absence as she takes on Marion Bartoli
Bartoli, the 14th seed, takes the first set but needs a medical time-out for a leg injury as Clijsters hits back to level the match
Clijsters ups the ante in the decider to clinch a 5-7 6-1 6-2 victory and reach the third round, where she will play another Belgian - Kirsten Flipkens - for a place in the last 16
All eyes are on Rafael Nadal as the former world number one returns to Grand Slam action after missing Wimbledon because of tendonitis in both knees
The Spaniard, who has slipped to third in the rankings during his enforced absence, is up against France's Richard Gasquet, who has also just returned to the game following his suspension
Nadal, who needs to win the US Open to complete a full set of Grand Slam titles, is just too powerful for the erratic Gasquet and his big-hitting game helps him breeze through the first two sets
Nadal makes only 10 unforced errors as he completes a 6-2 6-2 6-3 victory in one hour and 41 minutes to set up a second-round meeting with Germany's Nicolas Kiefer
The outside courts are a hive of activity as the first and second-round matches continue, with David Ferrer beating Alberto Martin on Court Four
Sixth seed Juan Martin del Potro is expected to be a serious contender for the title and begins in style with a three-set win over fellow Argentine Juan Monaco
Lleyton Hewitt won the tournament back in 2001 and sees off Juan Ignacio Chela in straight sets as he plans another tilt at the title
Roger Federer is in the unusual position of opening rather than closing the night session as he takes on Germany's Simon Greul
Federer does not have it all his own way and has to save set points before finally winning 6-3 7-5 7-5
Day three comes to a close with the final night match in front of a record crowd of 24,206, and Serena Williams leaves no doubt who the main attraction is
Williams plays magnificently and powers past Hungary's Melinda Czink 6-1 6-1 in just 53 minutes
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