PLEASE NOTE: We are unable to offer transcripts for our programme interviews. Today is broadcast live and the running order is subject to change.
The Work and Pensions Secretary, James Purnell, has resigned, becoming the first cabinet minister to openly tell Gordon Brown to stand aside for the sake of the Labour party. And the first results have been declared in the English local elections, with the Liberal Democrats and Conservatives taking control of one council each.
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Work and Pensions Secretary James Purnell has resigned, calling for Gordon Brown to leave office. As results from the local council elections start to come in, Labour MP Paul Farrelly and Professor John Curtice of Strathclyde University, discuss the fallout from the elections.
Most EU countries will not be releasing the results of their European Parliament elections until Sunday, but exit polls in the Netherlands suggest that the far right Freedom Party has done well. The party opposes both further immigration to the Netherlands and is against Turkey joining the EU. Correspondent Stephen Chittenden reports from The Hague on the latest results.
A Downing Street source has said a reshuffle is expected as early as this morning. Political correspondent Norman Smith reports on the latest developments.
The Medical Research Council has appointed a leading scientist to set up a new brain bank network. Correspondent Tom Feilden reports on the shortage of brains for medical research and the head of the brain bank network Professor James Ironside explains the importance of neurological research.
Barry Sheerman MP has called for a secret ballot of Labour MP to decide whether the parliamentary party had confidence in Gordon Brown. Mr Sheerman discusses his call for a vote.
0750 Thought for the day with the Chief Rabbi Sir Jonathan Sacks.
The chief probation officer who resigned after a damning report on the handling of double killer Dano Sonnex has said he is "profoundly sorry". David Scott discusses the mistakes the authority made, which led to Mr Sonnex being wrongly bailed.
The Work and Pensions Secretary, James Purnell, has resigned, urging Gordon Brown in his resignation letter to "stand aside." International Development Secretary Douglas Alexander, and political editor Nick Robinson discuss the impact of the resignation.
The relationship between music and painting has been explored in a project at the National Gallery over the last year. Composing Through Art saw 80 young composers writing short pieces of music inspired by one of the gallery's paintings. Artist Gayna Pelham and young composers Rachael Lockwood and Benjamin Vaughn discuss the project.
One year ago, 13-year-old Sam Leeson hanged himself in his bedroom following bullying both at school and online. Sam's mother Sally Cope and Dr Monica Whitty, of Nottingham Trent University, discuss whether enough is being done to raise awareness of online bullying.
A new European Parliament is set to emerge when poll results come out on Sunday night. Europe correspondent Jonny Dymond reports from Nuremburg in Germany at the final stop of his marathon trip around the EU.
Squeaky old houses, mysterious slamming doors, strange apparitions - everyone knows the basics of ghost stories. Ghost story writer James Buchan and John Sutherland, professor of English at University College London, discuss whether ghost stories are a credible form of storytelling in these sceptical times.
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Can Gordon Brown carry on as Prime Minister? Peter Riddell, assistant editor of The Times, and Trevor Kavanagh, associate editor of The Sun, discuss the future for Labour's leader.
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